Hi, I have a technical replicates with dye-swap as: Cy3 Cy5 ------------- wt1 mu1 mu1 wt1 wt2 mu2 mu2 wt2 wt3 mu3 mu3 wt3 wt4 mu4 mu4 wt4 designM <- c(1,-1,1,-1,1,-1,1,-1) corfit<- duplicateCorrelation(MAlist, designM, bloc=c(1,1,2,2,3,3,4,4)) fit<- lmFit(MAlist,design=designM,block=c(1,1,2,2,3,3,4,4), correlation=corfit$consensus) but I have this error message: Running plug-in: normalization.R Warning in Too much damping - convergence tolerance not achievable Error in paste(errMsg, "\n", sep = "") : argument "errMsg" is missing, with no default Execution halted Failed to execute R-script This error appears when creating the corfit variable. If someone can help me... Thanks Christelle -- Passerelle antivirus IGF --