Hi All,

I have large data set with methylation values ranging from 0-1. The data contains around 3 million rows of values corresponding to the chromosomal locations. I want to split/sort my data for plot using circos plot. I thought of doing like sorting the value range 0.2-0.4 as hypomethylation category and range 0.7-1.0 as hypermethylation category. However, with this approach the plot again looks cluttered. Another way is that I can split the data into two parts, one part with values lower than median, and another part with values larger than median.

Can anyone suggest me which approach is better or if there are other approaches I can implement in my datasets to make data possible for circos plot using circlize package.

Thanks.