I've noticed there is a bug when tying to run one sample on ENmix::bmiq.mc() and wanted to make a pull request. As this project lives on Bioconductor and not Github not sure the best way to do this (your repo says to fill bug reports here).

Error in 1:ncol(beta.b1) : argument of length 0

Adding the as.matrix() part will fix the problem.

The code can be seen here https://ibb.co/znB8s8P