Received via GitHub https://github.com/Oshlack/splatter/issues/47
I was wondering if it is possible to use Splatter to simulate cell outliers.
In the documentation of Splatter, there are expression outlier parameters, but I did not find any specific information on cell outliers. Excuse me if I missed anything. I only searched the keyword "outlier" in the documentation.
I thought about generating very small DE groups with large DE scale in Splatter as cell outliers, but I am not sure if it is appropriate or not.
I am trying to benchmark methods for detecting cell outliers. Although it is not very meaningful to identify a very small number of outliers in scRNA-seq datasets that usually contain thousands of cells, it may be a straightforward approach to reduce the noise in the datasets.
Any pointers would be appreciated!
By the way, I have been using Splatter to benchmark clustering methods, and it worked very smoothly. I appreciate your efforts on making the package reliable and easy to use.