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I would use Limma, with sib pairs as a block. This has all the advantages of a paired t-test with better power. At 12:53 PM 11/7/2005, Li,Qinghong,ST.LOUIS,Molecular Biology wrote: >Hi BioC, > >I have a data set from an experiemnt that has a control and a >treatment group for a total of 8 dogs. Each group has 4 bioloigical >replicates (4 dogs). Animals are in pairs in terms of siblings. Is >paired test appropriate in this case? > >Due to low replicate number (4), is traditional t test appropriate? >If not, what would be other options in BioC packages besides SAM? > >Thanks in advance! >Johnny > > > [[alternative HTML version deleted]] > >_______________________________________________ >Bioconductor mailing list >Bioconductor at stat.math.ethz.ch >https://stat.ethz.ch/mailman/listinfo/bioconductor Naomi S. Altman 814-865-3791 (voice) Associate Professor Dept. of Statistics 814-863-7114 (fax) Penn State University 814-865-1348 (Statistics) University Park, PA 16802-2111