Hi Jane, Which version of RMySQL are you running? The version you can get from the CRAN repository is 0.5.5 but there is a newer version (0.5.6) here: http://stat.bell-labs.com/RS-DBI/download/ Have you tried using that one? If this also doesn't work, we can contact the maintainer of the RMySQL package to see if he can provide us with an update. Note: If you would want to use biomaRt under Windows, I've put the latest biomaRt Windows build here: http://homes.esat.kuleuven.be/~sdurinck/biomaRt_1.5.1.zip best, Steffen Dear Mac users: more problems with bioC packages on Mac OSX: this time with biomaRt (R 2.2. and latest BioC release). It installs but then when i am doing martConnect() it complains about MySQL being out of date (but seems to establish connection). I actually downloaded the latest version of MySQL (v. 4.1.15, could not find 4.1.14 it is asking for: would that cause a problem?), reinstalled all the biomaRt dependencies (DBI and RMySQL) and then biomaRt but message remains the same ). mysql got installed into /usr/local/mysql/bin and the location is in the .bashrc path. I would not mind the message except when i try to do smthg with the package, e.g. getGene, R session automatically closes. Interestingly, I checked with Wolfgang Huber, one of the package authors and he says that he observed the same message of mysql being out of date on his linux but is able to run the examples without problems. I hope i am not flooding the list with my "BioC on Mac" questions. biomaRt was working fine under windows for me , at least in the previous iterations and was very useful. Thanks again Jane Disclaimer: http://www.kuleuven.be/cwis/email_disclaimer.htm