Dear All,

I want to install ToPASeq on R 3.4.2 but encountering problem that ToPASeq is available in source form and require compilation of C/C++/Fortran

kindly help me to rectify this problom

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> source("https://bioconductor.org/biocLite.R")

Bioconductor version 3.5 (BiocInstaller 1.26.1), ?biocLite for help
> biocLite("ToPASeq")
BioC_mirror: https://bioconductor.org
Using Bioconductor 3.5 (BiocInstaller 1.26.1), R 3.4.2 (2017-09-28).
Installing package(s) ‘ToPASeq’
Package which is only available in source form, and may need
  compilation of C/C++/Fortran: ‘ToPASeq’
  These will not be installed
installation path not writeable, unable to update packages: mgcv
> sessionInfo()
R version 3.4.2 (2017-09-28)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 7 x64 (build 7601) Service Pack 1

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.1252 
[2] LC_CTYPE=English_United States.1252   
[3] LC_MONETARY=English_United States.1252
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.1252    

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
[1] BiocInstaller_1.26.1

loaded via a namespace (and not attached):
[1] compiler_3.4.2 tools_3.4.2   

Usually this is red flag -- the package has not been compiled for your platform, probably because the author has written software that cannot (easily) be used on your platform.

From the package landing page, clicking on the 'platforms: some' tag http://bioconductor.org/packages/devel/bioc/html/ToPASeq.html#archives shows that this package is only available as a source installation, and not on Mac or Windows; the authors have chosen to not support these platforms, so your only solution is to use Linux.